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What Are Primary Immune Deficiencies?


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Primary immune deficiency (PID) disorders weaken the immune system, putting the body at greater risk for infections and other health problems. They are also called primary immunodeficiency disorders. Cases can be mild enough to go unnoticed for years and severe enough for doctors to diagnose at birth. With treatment, most people with PIDs lead full, normal lives.


The trademark sign of PIDs is a heightened vulnerability to infection. Illnesses may last longer, pop up more often or be more difficult to get rid of. Symptoms can vary across different types of PIDs, as well as from person to person. Some common symptoms include:

  • Frequent pneumonia, bronchitis, sinus infections, ear infections, skin infections or meningitis
  • Inflammatory infection of internal organs
  • Blood disorders
  • Digestive problems
  • Delayed growth and development
  • Autoimmune diseases


PIDs are often inherited when problems in DNA coding cause defects in the immune system. PIDs come in six broad groups:

  • B cell (antibody) deficiencies
  • T cell deficiencies
  • Both B and T cell deficiencies
  • Defective phagocytes
  • Complement deficiencies
  • Unknown (idiopathic)


Treatments can boost the immune system and protect from the worst of infections. If you suspect you or your child has a PID, speak with your doctor. Early detection can help avoid complications from infection.

Do you or someone you know have a primary immune deficiency? See if you qualify for IMMUNOe’s clinical research study on PIDs today!

Source: http://www.mayoclinic.org/diseases-conditions/primary-immunodeficiency/basics/definition/con-20031958

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